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【近5年来主要研究课题】 1.从事基于天然产物的创新药物研究：从天然产物中发掘苗头化合物，对苗头分子进行全合成及靶向性的结构优化，近年来已发现一些具有成药性的先导化合物，用以治疗糖尿病、慢性阻塞性肺炎、肺动脉高压等重大慢性疾病。 2.从事有机合成新方法的研究：开发高效的有机合成新方法来构建多样性的类药性分子实体（杂环化合物），而后进行活性筛选，助力药物先导分子的发现。 【近5年来主持项目】 1.国家自然科学基金面上项目：新骨架PKC系列抗炎天然分子的发现与研究（22177121）；2022.01-2025.12 2.上海市自然科学基金面上项目：天然抗炎活性物质的发现、合成及活性研究（20ZR1467800）；2020.07-2023.06 3.国家自然科学基金青年基金：抗COPD高选择性PDE4天然抑制剂的发现：SelaginpulvilinK的结构优化和生物活性研究（81703341）；2018.01-2020.12 【近5年来代表性论文】 1)Kai-Wen Hu#,Xiao You#,Jin-Zheng Wang,Xiaoan Wen,Hongbin Sun,* Qing-Long Xu,*,Zengwei Lai*.Chiral Phosphoric Acid Catalyzed Asymmetric Desymmetrization ofpara-Quinamines with Isocyanates: Access to Functionalized Imidazolidin-2-one Derivatives.Org. Lett.2021,23(20), 7873-7877. 2)Zengwei Lai#,Renwei Zhang#, Qiang Feng, Jianwei Sun*.3-Aminooxetanes: Versatile 1,3-Amphoteric Molecules for Intermolecular Annulation Reactions.Chem. Sci.2020,11, 9945-9949. (#:equal contribution) 3)Tianhua Zhang#,Zengwei Lai#,Shuyin Yuan, Yi-You Huang, Guoqiang Dong, Chunquan Sheng*, Hengming Ke*, Hai-Bin Luo*. Discovery ofEvodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.J. Med. Chem.2020, 63,17, 9828-9837. (#:equal contribution) 4)Chen Zhang, Qian Zhou, Xu-Nian Wu, Ya-Dan Huang, Jie Zhou,Zengwei Lai*, Yinnuo Wu*, Hai-Bin Luo. Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease.J. Enzym. Inhib. Med. Chem.2018,33(1), 260-270. 5)Zeng-Wei Lai, Chuan Liu, Hongbin Sun*, Shu-Li You*. Asymmetric Synthesis of 3-Allyloxindoles and 3-Allenyloxindoles by Scandium(III)-catalyzed Claisen Rearrangement Reactions.Chin. J. Chem.2017,35(10), 1512-1516. 【以往重要代表性论文】 1）Zengwei Lai,Zhaobin Wang, Jianwei Sun*.Organocatalytic Asymmetric Nucleophilic Addition to ortho-Quinone Methides by Alcohols.Org. Lett.2015,17(24), 6058-6061. 2）Zeng-Wei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Discovery of Highly Potent DPP-4 Inhibitors by Hybrid Compound Design Based on Linagliptin and Alogliptin.Eur. J. Med. Chem.2014,83, 547-560. 3）Yu-Rong Yang*,Zeng-Wei Lai,Liang Shen, Jiu-Zhong Huang,Xing-De Wu, Jun-Lin Yin and Kun Wei.Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction.Org. Lett.2010,12(15), 3430-3433. 【近5年主要授权专利】 1)一种1,1’-二茂铁全氟烷基膦氮配体、其制备方法及应用. CN 201410065244.8. 2)一类吴茱萸碱类化合物及其制备方法与应用. CN 201710245872.8.
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