【近5年来主要研究课题】 以酶作为主要催化元件的生物催化被认为是发展绿色高效合成方法的重要途径,而对于酶的设计和进化就是其中非常关键的影响因素之一。本课题组主要研究通过生物和化学技术手段,高效构建新型人工酶,实现人工酶催化的非天然反应,并阐明新酶催化反应机理,最终扩展酶催化反应的范畴以及酶在有机合成当中的应用。课题组在国际权威期刊发表高水平论文共计12篇,近五年以第一或通讯作者身份发表论文6篇,包括Nature Catalysis(1篇)、Nature Chemistry(1篇)、ACS Catalysis(1篇)、Organic Letters(1篇)等。
【近5年来代表性论文】 1.Z. Zhou*, G. Roelfes*. “Synergistic Catalysis of Tandem Michael Addition / Enantioselective Protonation Reactions by an Artificial Enzyme” ACS Catalysis2021, 11, 9366. 2.Z. Zhou, G. Roelfes*. “Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites” Nature Catalysis2020, 3, 289. 3.Z. Zhou, Z. X. Wang, Y.-C. Zhou, W. Xiao, Q. Ouyang, W. Du, Y.-C. Chen*.“Switchable regioselectivity in amine-catalysed asymmetric cycloadditions.”Nature Chemistry2017, 9, 590. 4.Z. Zhou,§Q. He,§Y. Jiang, W. Du, Y.-C. Chen*. “Double Thiol-Chiral Brønsted Base Catalysis: Asymmetric Cross Rauhut–Currier Reaction and Sequential [4 + 2] Annulation for Assembly of Different Activated Olefins” Organic Letters2019, 21, 7184. 5.Z. Zhou, Z. X. Wang, Q. Ouyang, W. Xiao, W. Du, Y.-C. Chen*. “Cross-conjugated trienamine catalysis witha¢-alkylidene cyclic enones: application inb,g-regioselective aza-Diels-Alder reaction.” Chemistry - A European Journal. 2017, 23, 2945. 6.L. O. Atta§,Z. Zhou§, G. Roelfes*. “In Vivo Biocatalytic Cascades Featuring an Artificial Enzyme Catalyzed New-to-Nature Reaction”ChemRxiv.2022. 7.R.B. Leveson-Gower,Z. Zhou, I. Drienovská, G. Roelfes*.Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase. ACS Catalysis2021, 11, 6763.
【近5年来主持项目】
[1] 含氮类新分子的生化反应设计与合成生物系统创建,国家重点研发计划“合成生物学”重点专项青年项目(2021YFA0911500),2021.12-2026.11,课题任务负责人。
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